What is Langerhans cell histiocytosis LCH? What causes Langerhans cell histiocytosis? Is Langerhans cell histiocytosis inherited? We hope this information is helpful.

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What is Langerhans cell histiocytosis LCH? What causes Langerhans cell histiocytosis? Is Langerhans cell histiocytosis inherited? We hope this information is helpful.

We strongly recommend you discuss this information with your doctor. If you still have questions, please contact us. Please see our Disclaimer. National Institutes of Health. COVID is an emerging, rapidly evolving situation. Menu Search Home Diseases Langerhans cell histiocytosis.

Back to List of Questions. Question Question. I believe that I was once told that this condition is not genetic. Is this true? Answer Answer. The following information may help to address your question: What is Langerhans cell histiocytosis LCH? LCH may be found in many areas of the body, including but not limited to the skin and nails, mouth, bones, lymph nodes , pituitary gland, and thyroid gland. When it is found in multiple areas of the body, it is known as multisystem disease.

LCH is not caused by a known infection, is not contagious, nor is it believed to be inherited. There remain differing opinions among experts as to whether it is definitively a cancer or not.

Because all the variants have many common symptoms it is thought that they may be manifestations of LCH and not separate syndromes. The cause of Langerhans cell histiocytosis LCH is unknown in many cases. Somatic gene mutations are acquired during a person's lifetime, which means they are acquired after conception and are only present in certain cells. Because they are not present in the germ cells egg and sperm , they are not passed on to the next generation are not inherited.

Somatic mutations cause the BRAF protein in affected cells to be continuously on and to transmit messages to the nucleus even in the absence of these chemical signals. The overactive protein may contribute to the development of LCH by allowing the Langerhans cells to grow and divide uncontrollably. Chemical signaling through this pathway is essential for normal development before birth. When mutated, oncogenes have the potential to cause normal cells to become cancerous.

Some researchers believe that additional factors, such as viral infections and environmental toxins , may also influence the development of this complex disorder. Smoking is strongly associated with lung LCH. Although Langerhans cell histiocytosis is generally considered a sporadic, non-hereditary condition, it has reportedly affected more than one individual in a family in a very limited number of cases particularly identical twins.

References References. LCH in Children. Histiocytosis Association of America. National Cancer Institute. Langerhans Cell Histiocytosis. Langerhans cell histiocytosis. Genetics Home Reference. BRAF gene. Br J Haematol. Share this content:. Close Copy Link. You May Be Interested In. How to Find a Disease Specialist. Tips for the Undiagnosed. Support for Patients and Families. Tips for Finding Financial Aid. Help with Travel Costs.

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Langerhans cell histiocytosis

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