The condition classically involves the corpus callosum with necrosis and demyelination. MBD is in most instances seen in chronic alcoholics, and as such the epidemiology reflects this demographic, with middle-aged to elderly male patients years of age being most commonly affected 2. The disease is attributed to a deficiency of all eight types of vitamin B group and results in necrosis and demyelination of the corpus callosum. Histologically, the myelin loss may be striking and may be accompanied by axonal degeneration 5. Prior to the advent of cross-sectional imaging, the diagnosis was only limited to postmortem examination and only the acute variety was diagnosed.
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Marchiafava-Bignami disease treated by mianserin hydrochloride in short-term evaluated by neuropsychological analysis. Psychogeriatrics ;
Marchiafava E, Bignami A. Sopra una alterazione del corpo calloso osservata in soggeti alcolisti. Riv Pat Nerv Ment ; Clin Neuropathol ; Morel F. Une forme anatomo-clinique particuliere de I; alcoolisme chronique: sclerose corticale laminaire alcoolique. Rev Neurol ;
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