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PubMed Central. Here we report a 1-y-old Mongolian gerbil with a spontaneous osteosarcoma at the level of the proximal tibia, with metastases to the pectoral muscles and lungs. Grossly, the tibial mass obliterated the tibia and adjacent muscles, and an axillary mass with a bloody, cavitary center expanded the pectoral muscles. Microscopically, the tibial mass was an infiltrative, osteoblastic mesenchymal neoplasm, and the axillary mass was an anaplastic mesenchymal neoplasm with hemorrhage.

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PubMed Central. Here we report a 1-y-old Mongolian gerbil with a spontaneous osteosarcoma at the level of the proximal tibia, with metastases to the pectoral muscles and lungs. Grossly, the tibial mass obliterated the tibia and adjacent muscles, and an axillary mass with a bloody, cavitary center expanded the pectoral muscles. Microscopically, the tibial mass was an infiltrative, osteoblastic mesenchymal neoplasm, and the axillary mass was an anaplastic mesenchymal neoplasm with hemorrhage.

The lung contained multiple metastatic foci. Immunohistochemistry for osteonectin was strongly positive in the tibial, axillary, and pulmonary metastases. Although osteosarcoma is the most common primary malignant bone neoplasm that occurs spontaneously in all laboratory and domestic animal species and humans, it arises less frequently than does other neoplasms. The current case of spontaneous osteoblastic osteosarcoma of the proximal tibia and metastases to the pectoral muscles and lung in a Mongolian gerbil is similar in presentation, histology, and predilection site of both osteoblastic and telangiectatic osteosarcomas in humans.

In addition, this case is an unusual manifestation of osteosarcoma in the appendicular skeleton of a Mongolian gerbil. The pathology of the Mongolian Gerbil Meriones unguiculatus : a review. Both naturally occurring disease processes and experimental models of human disease in the Mongolian gerbil were reviewed. The gerbil was highly susceptible to cerebral infarction following unilateral ligation of one common carotid artery and was useful in studies of the pathogenesis of stroke.

Spontaneous epileptiform seizures mimicked those of human idiopathic epilepsy, and both seizure-sensitive and resistant strains have been bred. Perhaps because of its more efficient nephron, the gerbil accumulated four to six times as much renal lead as the rat, and the gerbil has been proposed as an experimental model of lead nephropathy.

Some breeders exhibited hyperactivity of the adrenal cortex associated with hyperglycemia, hyperlipidemia and degenerative vascular disease. Although dietary supplements of cholesterol were toxic and did not induce atherosclerosis, the gerbil was useful in other studies of cholesterol absorption and metabolism. Spontaneous, insidious periodontal disease became evident after about 6 months on standard diets, and dental caries were induced by cariogenic diets or by pathodontic streptococci.

Spontaneous neoplasia occurred in 8. Adrenal cortical, ovarian and cutaneous tumors were the most consistently reported neoplasms. Helicobacter pylori genetic diversification in the Mongolian gerbil model. Helicobacter pylori requires genetic agility to infect new hosts and establish long-term colonization of changing gastric environments.

In this study, we analyzed H. This model is of particular interest because H. We analyzed the whole genome sequences of H. The mean annualized single nucleotide polymorphism SNP rate per site was 1. Many of the mutations occurred within or upstream of genes associated with iron-related functions fur , tonB1 , fecA2 , fecA3 , and frpB3 or encoding outer membrane proteins alpA, oipA, fecA2, fecA3, frpB3 and cagY. Several deletion or insertion mutations led to disruption of open reading frames, suggesting that the corresponding gene products are not required or are deleterious during chronic H.

Five variants three SNPs and two deletions were detected in isolates from multiple animals, which suggests that these mutations conferred a selective advantage. One of the mutations FurR88H detected in isolates from multiple animals was previously shown to confer increased resistance to oxidative stress, and we now show that this SNP also confers a survival advantage when H.

Collectively, these analyses allow the identification of mutations that are positively selected during H. Opiate receptor binding in the brain of the seizure sensitive Mongolian gerbil Meriones unguiculatus.

Opiate receptor binding was studied in seizure sensitive SS and seizure resistant SR strains of the Mongolian gerbil.

Cryostat sections of the brain were labeled with [3H]-dihydromorphine, subjected to autoradiography and analysed by microdensitometry. SS gerbils , prior to seizure induction, demonstrated overall greater brain opiate binding when compared to SR animals.

Immediately following a seizure, binding in the interpeduncular nucleus fell to levels found in SR animals. The increased opiate binding in the SS pre-seizure compared to SR gerbils could reflect a deficit of endogenous ligand which could underlie the seizure diathesis in the gerbil. Glucose supplement reverses the fasting-induced suppression of cellular immunity in Mongolian gerbils Meriones unguiculatus. Glucose plays an important role in immunity. Three day fasting will decrease cellular immunity and blood glucose levels in Mongolian gerbils Meriones unguiculatus.

In the present study, we tested the hypothesis that glucose supplement can reverse the fasting-induced suppression in cellular immunity in gerbils. Twenty-eight male gerbils were selected and randomly divided into fed and fasting groups. After 66 h, each gerbil was injected with phytohaemagglutinin PHA solution to challenge cellular immunity.

Results showed that glucose supplement restored blood glucose levels in fasted gerbils to those of the fed controls. It also recovered cellular immunity, body fat mass and serum leptin levels in fasted gerbils to the values of the fed controls. Blood glucose levels were positively correlated with body fat mass, leptin levels and cellular immune responses.

Thymus and spleen masses, and white blood cells in fasted gerbils were not affected by glucose supplement. In general, our data demonstrate that glucose supplement could reverse fasting-induced suppression of cellular immunity in Mongolian gerbils. All rights reserved. Analysis of the microflora in the stomach of Mongolian gerbils infected with Helicobacter pylori.

Mongolian gerbils are frequently used to study Helicobacter pylori-induced gastritis and its consequences. The presence of some gastric flora with a suppressive effect on H. The aim of the present study was to analyze the microflora in the stomach of Mongolian gerbils with H. Gastric microflora were isolated by aerobic and anaerobic culture, and the identification of gastric bacterial species was performed by API20E and API20A. Oral administration of H. According to the frequency of detection of H.

According to the analysis of the gastric microflora in the frequently and infrequently detected groups, Lactobacillus spp. Some gastric flora, such as Lactobacillus spp. Fasting suppresses T cell-mediated immunity in female Mongolian gerbils Meriones unguiculatus. Immune defense is important for organisms' survival and fitness. Small mammals in temperate zone often face seasonal food shortages. Generally fasting can suppress immune function in laboratory rodents and little information is available for wild rodents.

The present study tested the hypothesis that Mongolian gerbils Meriones unguiculatus could inhibit T cell-mediated immunity to adapt to acute fasting. Forty-two females were divided into the fed and fasted groups, in which the latter was deprived of food for 3days. After 66h fasting, half of the gerbils in each group were injected with phosphate buffered saline or phytohaemagglutinin PHA solution. T cell-mediated immunity assessed by PHA response was suppressed in the fasted gerbils compared with the fed gerbils.

The fasted gerbils had lower body fat mass, wet and dry thymus mass, dry spleen mass, white blood cells, serum leptin and blood glucose concentrations, but higher corticosterone concentrations than those of the controls. Moreover, PHA response was positively correlated with body fat mass and serum leptin levels in the immunochallenged groups. Taken together, acute fasting leads to immunosuppression, which might be caused by low body fat mass and low serum leptin concentrations in female Mongolian gerbils.

Helicobacter suis causes severe gastric pathology in mouse and mongolian gerbil models of human gastric disease. It has been shown to be identical to H. To obtain better insights into the long-term pathogenesis of infections with this micro-organism, experimental infections were carried out in different rodent models. Gastric tissue samples were collected for PCR analysis, histological and ultrastructural examination.

In both mice strains, bacteria colonized the entire glandular stomach. Colonization with H. From 9 weeks after infection onwards, an increased proliferation rate of mucosal epithelial cells was detected in the stomach regions colonized with H. At 8 months post infection, severe destruction of the normal antral architecture at the inflamed sites and development of mucosa-associated lymphoid tissue MALT lymphoma-like lesions were observed in some gerbils.

In mice, the inflammatory response was less pronounced than in gerbils , consisting mainly of mononuclear cell infiltration and being most severe in the fundus. Therefore, the possible involvement of this micro-organism in human gastric disease. Comparative analysis of gastric bacterial microbiota in Mongolian gerbils after long-term infection with Helicobacter pylori. Quantitative qt real time PCR using 16SrDNA primers is useful for determination of the bacterial composition of the gastric microbiota in Mongolian gerbils.

The aim of this study was to determine the change in the gastric microbiota after long-term infection with Helicobacter pylori. One year after inoculation with H. The gastric microbiota of each group of gerbils was also compared with that of 6 gerbils uninfected with H.

DNA from the Atopobium cluster, Bifidobacterium spp. In contrast, Eubacterium cylindroides group and Prevotella spp. The numbers of C. The results obtained suggest that the composition of gastric indigenous microbiota in Mongolian gerbils may be disturbed by long-term infection with H. Development of wide-band middle ear transmission in the Mongolian gerbil. Stapes vibrations were measured in deeply anesthetized adult and neonatal ages: 14 to 20 days Mongolian gerbils.

In adult gerbils , the velocity magnitude of stapes responses to tones was approximately constant over the entire frequency range of measurements, 1 to 40 kHz. In neonatal gerbils , the sensitivity of stapes responses to tones was lower than in adults, especially at mid-frequencies e. The input impedance of the adult gerbil cochlea, calculated from stapes vibrations and published measurements of pressure in scala vestibuli near the oval window [E.

Olson, J. Conclusions: a middle-ear vibrations in adult gerbils do not limit the input to the cochlea up to at least 40 kHz, i. Environmental effects on the ontogeny of exploratory and escape behaviors of Mongolian gerbils. Mongolian gerbils reared in standard laboratory cages and gerbils reared in cages containing a burrowlike shelter did not differ in their rate of development of escape responses to sudden visual stimulation.

The presence of shelter in the rearing environment did, however, markedly slow the development of adult-like patterns of exploration. Reduced exposure to illumination, experienced by shelter-reared subjects, proved responsible for this retardation of development. The effect of shelter-rearing on the development of exploratory behavior is interpreted as demonstrating an environmentally induced maintenance of an adaptive juvenile pattern of behavior.

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Plojhar, Josef Overview. Publication Timeline. Most widely held works about Josef Plojhar. Most widely held works by Josef Plojhar. Health care in Czechoslovakia by Josef Plojhar Book 7 editions published in in English and Czech and held by 19 WorldCat member libraries worldwide. Buchenwald mahnt by Josef Plojhar Book 3 editions published in in German and Undetermined and held by 15 WorldCat member libraries worldwide.

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