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Ou seja, inibe as imunidades celular e humoral e a fase efetora da resposta imune. Leucometria abaixo de 4. Se a leucopenia for inferior a 2. Tais sintomas podem ocorrer somente nas primeiras semanas ou ser intensos e dose-limitantes. A dose semanal varia entre 7,5mg e 25mg. As doses administradas devem ser registradas pelo paciente para acompanhamento do total acumulado. Sendo assim, recomenda-se coletar as amostras cinco a sete dias depois. Grau IIIB: fibrose moderada a grave - suspender o tratamento;.

Grau IV: cirrose - suspender o tratamento e fazer avaliar conjunta com o gastroenterologista. Outros efeitos a longo prazo incluem:. Alguns fatores precisam ser analisados. A droga se apresenta em comprimidos de 25mg e 50mg e em ampolas de mg. No primeiro dia, realiza-se pulso de ciclofosfamida e dexametasona seguidos. No segundo e terceiro dias, usa-se apenas dexametasona. A ciclofosfamida 1. Combinada com outras drogas: vasculites, colagenoses. Dessa forma, pode-se oferecer melhor qualidade de vida ao paciente com menores riscos.

Kiss MHB. Reumatologia Essencial. Guanabara Koogan; Manfro RC. Revista Virtual de Medicina, Danovitch G. Imunosuppressive medications for renal transplantation: a multiple choice question. Kidney Int. Bras Dermatol. Systemic drugs. London: Mosby Elsevier; Pharmacogenomics and Dermatological Therapeutics.

Arch Dermatol. Pregnancy and the drug dilemma, Halverstam CP, Lebwohl M. Nonstandard and off-label therapies for psoriasis. Clin Dermatol. Wise M, Callen JP. Azathioprine: a guide for the management of dermatology patients. Dermatol Ther. Reumatologia essencial. Rio de Janeiro: Guanabara Koogan; Azathioprine in dermatology: the past, the present, the future.

J Am Acad Dermatol. Marques AS. In: Sociedade Brasileira de Dermatologia. An Bras Dermatol. Methotrexate treatment in 13 children with severe plaque psoriasis. Clin Exp Dermatol. Martins GA, Arruda L. Update on the natural history and systemic treatment of psoriasis.

Adv Dermatol. Lima HC. Fatos e mitos sobre imunomoduladores. Cytotoxic agents. In: Comprehensive Dermatologic Drug Therapy. Wolverton SE. China: Saunders Elsevier; Pulsoterapia em buloses: relato de nove casos. Granulomatose de Wegener. In: Comprehensive dermatologic drug therapy. Saunders Elsevier. Yamada, Sacramento, Simis e Bohnenstengel. Systemic cyclosporine and tacrolimus in dermatology. Dermatologic Therapic. Rivitti EA. Ciclosporin in psoriasis clinical practice: an international consensus statement.

Br J Dermatol. Update on the use of cyclosporine in immune-mediated dematoses. Ho VC. The use of ciclosporin in psoriasis: a clinical review. Takahashi MDF. Systemic therapies for psoriasis: methotrexate, retinoids, and cyclosporine. Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients. Mycophenolate mofetil in dermatology. Treatment of pemphigus vulgaris with mycofenolate mofetil as a steroid-sparing agent. Eur J Dermatol. A comparision of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus.

A comparision of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of bullous pemphigoid. Mycophenolate mofetil as an adjuvant therapy for classic and endemic pemphigus foliaceus. J Dermatol. Dermatoses bolhosas auto-imunes. Drug interactions. Conflito de interesse: Nenhum Suporte financeiro: Nenhum. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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