Spinal cord injury. Literature update: physiopathology and initial treatment. Equipo de Columna Vertebral. Hospital del Trabajador de Santiago. The pathophysiology of spinal cord injury SCI is complex and still not fully elucidated. Primary and secondary processes determine SCI.
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Spinal cord injury. Literature update: physiopathology and initial treatment. Equipo de Columna Vertebral. Hospital del Trabajador de Santiago. The pathophysiology of spinal cord injury SCI is complex and still not fully elucidated. Primary and secondary processes determine SCI. The initial injury is produced by the transmission of the mechanical energy of the trauma to the spinal cord and neural structures.
The secondary injury acts on those structures that were spared by the initial trauma, affecting microvascular perfusion and ionic concentrations, inducing the liberation of free radicals and neurotransmitters and activating lipid peroxidation, thus producing cellular death. Recent research in the treatment of SCI is focused on the development of timely therapeutic interventions that could attenuate the effects of these secondary pathophysiological mechanisms.
Among the pharmacological interventions, methyl-prednisolone, gangliosides and antagonists of opiod, glutamate receptor and ionic channels have been used, advocating their theoretical protective effect in the neurological prognosis of patients with SCI. Nevertheless, none of these interventions has yet significantly modified this prognosis. Fase Inmediata 0 - 2 horas. Fase Aguda 2 - 48 horas. Mediadores inflamatorios y respuesta inmune celular.
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Soc Neurosci. Pharmacological therapy of spinal cord injury during the acute phase. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. Lorena, cj. How to cite this article.
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