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Sen, R. Badmanaban and C. Abstract Certain picric acid and paracetamol derivatives have been synthesized in good yields and tested against E. Coli, S. Characterization of new compounds has been done by means of spectral data and elemental analysis. Key Words: Picric acid and paracetamol derivatives, anti-microbial and anti-fungal activity. The treatment of infectious diseases still remains an important and challenging problem because of a combination of factors including emerging infectious diseases and the increasing number of multi-drug resistant microbial pathogens with particular relevance for Gram positive bacteria [1].

Bacteria are among the oldest living organisms on earth and are very small. Because the bacteria structure is so minute, it can only be seen through a microscope [2]. Bacteria are commonly found in the ground, water and in other living organisms. While some types of bacteria can cause diseases and become harmful to the environment, animals and humans, others offer benefits that we likely could not live without. Some types of bacteria can attack plants, causing diseases like leaf spot and fire blight.

Picric acid is the chemical compound formally called 2, 4, 6-trinitrophenol TNP. This, a yellow crystalline solid, is one of the most acidic phenols. TNT, picric acid is an explosive. Paracetamol or acetaminophen is a widely used over-the-counter analgesic pain reliever and antipyretic fever reducer. It is commonly used for the relief of fever, headaches, and other minor aches and pains, and is a major ingredient in numerous cold and flu remedies.

Biological activity of picric acid like Anti-Fungal [5], Anti- microbial[6]. Biological activity of paracetamol Anti- inflammatory, Anti-pyretic [7], Analgesic and slightly Anti-microbial and Anti-fungal activity[7].

These compounds also screened for their anti-microbial Anti-fungal activity []. Experimental Melting points of all the synthesized compounds were determined in open capillaries and are uncorrected.

Mass spectra were obtained using EV Shimadzu instrument. All the chemicals were used for the synthesis of titled compounds was procured from S. Fine Chem. Synthesis of picric acid derivatives Compound a-d : Preparation of 2, 4-diaminonitro phenol: Prepare a solution of Sodium-polysulphide by dissolving 40 gm of crystallized sodium-sulphide Na2S. Heat a mixture of 25 gm of picric acid and ml of H2O contained in a 1 liter beaker, until the water boils gently stir the solution, mechanically, place the sodium poly sulphide solution in a dropping funnel and clamp the funnel.

So, that the end of the stem is immediately above the beaker. Add the sodium-polysulphide solution during minute to the vigorously stirred, boiling mixture, and boil gently for a future 20 min. Allow to cool, this can be accomplished more rapidly by adding ice, filter at the pump and wash with cool water.

Trans to a ml beaker containing ml of water and 35 ml of conc. HCl and boil for 15 min. The m-nitro aniline dissolves leaving the sulphur and any unchanged picric acid filter and ppts m-nitro aniline from the filtrate by the addition of excess of concentrated aqueous NH3 solution filter off the product and recrystallized it from boiling water.

The yield of obtained. This product is intermediated. Dry the Precipitate and crystallized form dilute alcohol or methanol yielded 35 gm. Add Methanol 10 ml. Then, put 1 hr reflux in round bottom flask in heating metel. Cool and ice water and product are obtained. Dry the Precipitate and crystallized form dilute alcohol or methanol yielded 2 gm.

Dry the Precipitate and crystallized form dilute alcohol or methanol yielded 0. Synthesis of 2, 4-chloro acetamido nitro phenol: Add 5 gm product of 2, 4- diamino nitro phenol M.

K2CO3 add as catalyst. Dry the Precipitate and crystallized form dilute. Dry the Precipitate and crystallized form dilute alcohol or methanol yielded 1. Synthesis of p-aminophenol derivatives compound e-h : Synthesis of N- 4-hydroxyphenyl acetamide PCM : Add 5 gm product of p-aminophenol M. Dry the Precipitate and crystallized form dilute alcohol or methanol yielded 4. Synthesis of N- 4-hydroxy phenyl [ isobutyl phenyl]3-oxo pentanamide e : Add 1 gm product of N- 4-hydroxyphenyl acetamido M.

Synthesis of 2-chloro -N- 4-hydroxyphenyl acetamide: Add 5 gm product of P-aminophenol M. Synthesis of N- 4-hydroxy phenyl [ 4-sulfamo phenyl amino] acetamido h : Add 1 gm product of 2-Chloro -N- 4-hydroxyphenyl acetamido M.

Molecular M. Wt Mass Spectral Data I. Antimicrobial Activity The Synthesized compounds a-h were screened for their in vitro antimicrobial activity against Staphylococcus citrus, Staphylococcus aureus, Bacillus subtillus, Escheichio coli, and antifungal activity against Aspargillus niger, Candidas Albicans by measuring the zone of inhibition in mm. Nutrient agar was employed as culture medium and methanol was used as solvent control.

Streptomycin and Griseofulvin were used as standard for antibacterial and antifungal activities respectively []. Antifungal a Code a a Zone of inhibition mm Zone of inhibition mm A. The antibacterial screening data revealed that the compounds posses moderate activity.

From the antimicrobial screening it was observed that all the compounds exhibited activity against all the organisms employed. Looking at the structure activity relationship marked inhibition in bacteria was observed the compound bearing Para amino phenol derivatives like PABA, diclofenac, ibuprofen, p-amino benzene sulphonamide showed moderate to good activity. Fungicidal screening data also revealed that all the compounds showed moderate as compared to standard.

As we consider all result obtained from antibacterial and antifungal tests together we can say that entire compounds tested are active towards bacteria and fungi. SAR Picric acid carrying Nitro ring possesses greater antimicrobial and antifungal activity than P-amino phenol. More specifically an electron withdrawing group like Chloro and nitro substitution at 2,4 position exhibits greater anti microbial activity than their counters electron donors.

PCM ring is increase the potency of picric acid rings. Hence, it is concluded that there is scope for further study in developing these as good lead compounds. Acta Crystallogr. Briggs; Toan B. Nguyen; William L. New York: Wiley- Intrscience publication; Industrial and Manufacturing Chemistry, Part 1, Organic.

London: Crosby Lockwood, ; — The second Boer War, Hudson- Kimberly, ; The Great War. London and New York: Routeladge Classics, Indian Pharmacopeia ; 2nd Ed: p. Pharmaceutical Microbiology Experiments and Techniques. Career Publication; , 2nd ed: p. J Indian Chem ; Pediatr Int ; 45 6 : — Learn more about Scribd Membership Home. Much more than documents. Discover everything Scribd has to offer, including books and audiobooks from major publishers.

Start Free Trial Cancel anytime. Uploaded by Aulia Yolanda. Document Information click to expand document information Date uploaded Nov 25, Did you find this document useful? Is this content inappropriate? Report this Document. Flag for Inappropriate Content.

Download Now. Related titles. Carousel Previous Carousel Next. Jump to Page. Search inside document. Available on line www. Materials and Methods Experimental Melting points of all the synthesized compounds were determined in open capillaries and are uncorrected. Physicochemical data of the compounds a-h Compound.

Spectral data of the compounds a-h Compound. References [1] Schweppe, Helmut. Elenor Abrigo.


Jurnal Ilmu Kimia Universitas Brawijaya

He a lth. Re a c tiv ity. Material Safety Data Sheet. Picric acid MSDS.


Meaning of "Pikrat" in the German dictionary

Educalingo cookies are used to personalize ads and get web traffic statistics. We also share information about the use of the site with our social media, advertising and analytics partners. Meaning of "Pikrat" in the German dictionary. Salt of picric acid. Synonyms and antonyms of Pikrat in the German dictionary of synonyms.



View My Stats. Jumlah kreatinin yang diekskresikan melalui urin menunjukkan keadaan ginjal seseorang. Dalam penelitian ini, dikembangkan metode untuk penentuan kreatinin secara otomatis yaitu sequential injection-flow reversal mixing SI-FRM. Pendeteksian kreatinin didasarkan pada pembentukan senyawa berwarna merah-orange yang dihasilkan dari reaksi antara kreatinin dan asam pikrat dalam suasana basa dan diukur pada panjang gelombang nm.

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